Based on the notions and assumptions of the discourse of “new urban regionalism”, there is a close relationship between the "spatial morphological structure" and the "spatial division of labor" in a megalopolis region, and solving existing problems in one without another is not possible, because they can either act in the direction of positive reinforcement and support, or in order to weaken and become an obstacle to each other; therefore, what is meant by the problem of achieving equilibrium and integration in the spatial structure and the functional system in a megalopolis region, will not be possible without recognizing the nature and relationship between these two. The reviews done the research shows that "spatial morphological structure" and "spatial division of labor" in Tehran's megalopolis region during the recent decades has not been able to support each other and significantly reduce the spatial non-equilibrium in the region. Therefore, according to the results obtained in the framework of this study, the "spatial morphological structure" and "spatial division of labor" in Tehran's megalopolis region during the recent decades (1345-1390), has been accompanied by a significant reduction in the spatial non-equilibrium in the region, though, the trend of transformations is on the move. One of the strategic implications of this is that the future issue of the Tehran's megalopolis region is to be more focused on the peripheral population poles and the improvement of the level of performance of the city itself in order to accept transnational functions and create alternatives and opportunities for roles and the tasks that will be assigned to them in the future. Just as in the prior years the industry sector has gradually shifted to the service sector, in the future it also seems necessary to give up the services sector to itself periphery and oppose the acceptance of the fourth sector of the global economy (such as; Information, communication and cultural economy).